文献类型： 外文期刊
作者： Lin, Changchun 1 ; Wang, Weimin 3 ; Zhang, Deyin 3 ; Huang, Kai 3 ; Zhang, Yukun 3 ; Li, Xiaolong 3 ; Zhao, Yuan 3 ; Zhao, Liming 3 ; Wang, Jianghui 1 ; Zhou, Bubo 1 ; Cheng, Jiangbo 3 ; Xu, Dan 1 ; Li, Wenxin 1 ; Zhang, Xiaoxue 1 ; Zheng, Wenxin 2 ;
作者机构： 1.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou, Gansu, Peoples R China
2.Xinjiang Acad Anim Sci, Inst Anim Husb Qual Stand, Urumqi, Xinjiang, Peoples R China
3.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agroecosyst, Lanzhou, Gansu, Peoples R China
关键词： miRNA; residual feed intake; gene interactions; liver; sheep
期刊名称：FRONTIERS IN GENETICS （ 影响因子：3.7； 五年影响因子：4.3 ）
ISSN：
年卷期： 2023 年 14 卷
页码：
收录情况： SCI
摘要： Feed efficiency (FE), an important economic trait in sheep production, is indirectly assessed by residual feed intake (RFI). However, RFI in sheep is varied, and the molecular processes that regulate RFI are unclear. It is thus vital to investigate the molecular mechanism of RFI to developing a feed-efficient sheep. The miRNA-sequencing (RNA-Seq) was utilized to investigate miRNAs in liver tissue of 6 out of 137 sheep with extreme RFI phenotypic values. In these animals, as a typical metric of FE, RFI was used to distinguish differentially expressed miRNAs (DE_miRNAs) between animals with high (n = 3) and low (n = 3) phenotypic values. A total of 247 miRNAs were discovered in sheep, with four differentially expressed miRNAs (DE_miRNAs) detected. Among these DE_miRNAs, three were found to be upregulated and one was downregulated in animals with low residual feed intake (Low_RFI) compared to those with high residual feed intake (High_RFI). The target genes of DE_miRNAs were primarily associated with metabolic processes and biosynthetic process regulation. Furthermore, they were also considerably enriched in the FE related to glycolysis, protein synthesis and degradation, and amino acid biosynthesis pathways. Six genes were identified by co-expression analysis of DE_miRNAs target with DE_mRNAs. These results provide a theoretical basis for us to understand the sheep liver miRNAs in RFI molecular regulation.
- 相关文献
作者其他论文 更多>>
-
Identification of the FGB gene polymorphism and analysis of its association with fat deposition traits in Hu sheep
作者：He, Lijuan;Wang, Xiaojuan;Xu, Dan;Ma, Zongwu;Yang, Xiaobin;Huang, Zhiqiang;Cai, Youxin;Liu, Xiaoqiang;Chen, Zhanyu;Zhang, Xiaoxue;Wang, Weimin;Zhang, Deyin;Zhang, Yukun;Zhao, Yuan;Zhao, Liming;Li, Xiaolong;Cheng, Jiangbo;Weng, Xiuxiu;Lin, Changchun;Gong, Ping
关键词：Association analysis; Hu sheep; single nucleotide polymorphism; fat deposition; FGB gene
-
Monitoring Cattle Ruminating Behavior Based on an Improved Keypoint Detection Model
作者：Li, Jinxing;Liu, Yanhong;Li, Jinxing;Liu, Yanhong;Guo, Leifeng;Li, Jinxing;Liu, Yanhong;Li, Jinxing;Liu, Yanhong;Zheng, Wenxin;Chen, Xinwen;Ma, Yabin
关键词：cattle; improved YOLOv8-pose; rumination behavior; peak detection
-
The Role of BMP7 in the Proliferation of Hu Sheep Dermal Papilla Cells Is Influenced by DNA Methylation
作者：Lv, Xiaoyang;Sun, Wei;Lv, Xiaoyang;He, Mingliang;Wang, Shanhe;Sun, Wei;Lv, Xiaoyang;Wang, Shanhe;Sun, Wei;Zheng, Wenxin;Zhou, Hanlin;Mwacharo, Joram M.
关键词：Hu sheep; lamb skin; BMP7 gene; methylation; dermal papilla cell
-
The genetic characterization of germplasm and identification of the litter size trait associated candidate genes in Dexin mutton and fine-wool sheep
作者：Zhu, Mengting;Li, Pengfei;Lin, Changchun;Aladaer, Qi;Li, Pengfei;Wu, Weiwei;Zheng, Wenxin;Huang, Juncheng;Tulafu, Hanikzi;Lin, Changchun;Tao, Weikun
关键词：Dexin mutton and fine-wool sheep; litter size trait; selection signature; candidate genes; whole-genome resequencing
-
Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep
作者：Liang, Benmeng;Bai, Tianyou;Zhao, Yuhetian;Han, Jiangang;He, Xiaohong;Pu, Yabin;Ma, Yuehui;Jiang, Lin;Liang, Benmeng;Liu, Jianfeng;Liang, Benmeng;Liu, Jianfeng;Liang, Benmeng;Bai, Tianyou;Zhao, Yuhetian;Han, Jiangang;He, Xiaohong;Pu, Yabin;Ma, Yuehui;Jiang, Lin;Han, Jiangang;Wang, Chunxin;Liu, Wujun;Ma, Qing;Tian, Kechuan;Tian, Kechuan;Zheng, Wenxin;Liu, Nan
关键词：Chinese fine wool sheep; Whole genome sequencing; Genomic selection signature; Follicle density; Missense; Regulatory
-
Development of a Device and Algorithm Research for Akhal-Teke Activity Level Analysis
作者：Chen, Xuan;Li, Fuzhong;Fan, Qijie;Chen, Xuan;Li, Jinxing;Fan, Qijie;Guo, Leifeng;Li, Jinxing;Kwan, Paul;Zheng, Wenxin
关键词：activity level classification; horse; sensors; threshold analysis
-
Identification of AGO2 and PLEC genes polymorphisms in Hu sheep and their relationship with body size traits
作者：Liu, Jia;Yang, Xiaobin;Huang, Yongliang;Cui, Panpan;Ma, Zongwu;Zeng, Xiwen;Zhai, Rui;Zhang, Xiaoxue;Zheng, Wenxin;Wang, Weimin;Weng, Xiuxiu;Wu, Weiwei
关键词：Hu sheep; AGO2; pLEC; body size traits; qRT-PCR
