文献类型： 外文期刊

作者： Guo, Baoping ¹ ; Zhang, Zhuangzhi ³ ; Guo, Yongzhong ⁴ ; Guo, Gang ¹ ; Wang, Haiyan ⁵ ; Ma, Jianjun ⁶ ; Chen, Ronggui; ¹ ;

作者机构： 1.Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Urumqi, Xinjiang, Peoples R China

2.Xinjiang Med Univ, Affiliated Hosp 1, WHO Collaborating Ctr Prevent & Care Management E, Urumqi, Xinjiang, Peoples R China

3.Xinjiang Acad Anim Sci, Vet Res Inst, Urumqi, Xinjiang, Peoples R China

4.Friendship Hosp Yili Kazak Autonomous Prefecture, Yining, Xinjiang, Peoples R China

5.Chabuchaer Ctr Dis Control & Prevent, Chabuchaer, Xinjiang, Peoples R China

6.Xinyuan Ctr Dis Control & Prevent, Xinyuan, Xinjiang, Peoples R China

7.Yili Ctr Anim Dis Control & Prevent, Yining, Xinjiang, Peoples R China

8.Univ Franche Comte, Chronoenvironm Lab, UMR6249, Besancon, France

9.CNRS, Besancon, France

10.UK Ctr Ecol & Hydrol, Land Use Grp, Lancaster, England

11.QIMR Berghofer Med Res Inst, Infect Dis Program, Mol Parasitol Lab, Brisbane, Qld, Australia

期刊名称：PLOS NEGLECTED TROPICAL DISEASES （ 影响因子：4.411； 五年影响因子：4.898 ）

ISSN： 1935-2735

年卷期： 2021 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Author summary Alveolar echinococcosis (AE) is a neglected zoonosis caused by the larval stage of the fox/dog tapeworm Echinococcus multilocularis. In this study, we collected data on 286 AE cases reported from Yili Prefecture, Xinjiang Autonomous Region, the People's Republic of China from 1989 to 2015 with an annual incidence (AI) of 0.41/100,000. Among the patients, 73.08% were diagnosed in the last 11 years. The incidence (0.51-1.22 cases/100,000 residents) was higher in the high-altitude mountainous areas than those in low level areas (0.19-0.29/100,000 residents). In term of ethnic group, the AI of AE in Mongolian (2.06/100,000 residents) and Kazak (0.93/100,000) groups had higher incidence than the other ethnic groups, indicating sheep-farming activity is a risk for infection given that sheep farming is mainly practiced by these two groups in the prefecture. A total of 1411 small mammals were captured with 9.14% infected with E. multilocularis metacestodes. Microtus obscurus was the dominant species captured in the mountainous pasture areas with 15.01% infection rate, whereas Mus musculus and Apodemus sylvaticus were the dominant small mammals in the low altitude areas. Only 0.40% of A. sylvaticus were infected with E. multilocularis. These findings show that Yili Prefecture is a highly endemic area for AE and that the high-altitude pasture areas favorable for M. obscurus may play an important role in its transmission in this region. Alveolar echinococcosis (AE) is a life-threatening disease in humans caused by the larval stage of Echinococcus multilocularis. The tapeworm is transmitted between small mammals and dogs/foxes in the Northern Hemisphere. In this study 286 AE cases were reported from eight counties and one city in Yili Prefecture, Xinjiang Autonomous Region, the People's Republic of China from 1989 to 2015 with an annual incidence (AI) of 0.41/100,000. Among the patients, 73.08% were diagnosed in the last 11 years. Four counties in the high mountainous areas showed higher AI (0.51-1.22 cases//100,000 residents) than the four counties in low level areas (0.19-0.29/100,000 residents). The AI of AE in Mongolian (2.06/100,000 residents) and Kazak (0.93/100,000 residents) ethnic groups was higher than the incidence in other ethnic groups indicating sheep-farming is a risk for infection given this activity is mainly practiced by these two groups in the prefecture. A total of 1411 small mammals were captured with 9.14% infected with E. multilocularis metacestodes. Microtus obscurus was the dominant species in the mountain pasture areas with 15.01% of the voles infected, whereas Mus musculus and Apodemus sylvaticus were the dominant small mammals in the low altitude areas. Only 0.40% of A. sylvaticus were infected with E. multilocularis. PCR amplification and sequencing analysis of the mitochondrial cox1 gene showed that E. multilocularis DNA sequences from the small mammals were identical to isolates of local human AE cases. The overall results show that Yili Prefecture is a highly endemic area for AE and that the high-altitude pasture areas favorable for M. obscurus may play an important role in its transmission in this region.