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Polymorphisms in SHISA3 and RFC3 genes and their association with feed conversion ratio in Hu sheep

文献类型： 外文期刊

作者： Lin, Changchun 1 ; Wang, Weimin 2 ; Zhang, Deyin 2 ; Huang, Kai 2 ; Li, Xiaolong 1 ; Zhang, Yukun 2 ; Zhao, Yuan 2 ; Wang, Jianghui 1 ; Zhou, Bubo 1 ; Cheng, Jiangbo 1 ; Xu, Dan 1 ; Li, Wenxin 1 ; Zhao, Liming 1 ; Ma, Zongwu 1 ; Yang, Xiaobin 1 ; Huang, Yongliang 1 ; Cui, Panpan 1 ; Liu, Jia 1 ; Zeng, Xiwen 1 ; Zhai, Rui 1 ; Sun, Landi 2 ; Weng, Xiuxiu 2 ; Wu, Weiwei 3 ; Zhang, Xiaoxue 1 ; Zheng, Wenxin 4 ;

作者机构： 1.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou, Peoples R China

2.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agroecosystems, Lanzhou, Peoples R China

3.Xinjiang Acad Anim Sci, Inst Anim Sci, Urumqi, Xinjiang, Peoples R China

4.Xinjiang Acad Anim Sci, Inst Anim Husb Qual Stand, Urumqi, Xinjiang, Peoples R China

关键词： association analysis; SHISA3; RFC3; feed conversion ratio; tissue expression; Hu sheep

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.2； 五年影响因子：3.5 ）

ISSN：

年卷期： 2023 年 9 卷

页码：

收录情况： SCI

摘要： In animal husbandry, feed efficiency is a crucial economic trait. In this study, the general linear model was used to perform association analysis for various genotypes and feed conversion ratio (FCR)-related traits. Reverse transcription-quantitative PCR (RT-qPCR) was used to detect the expression of SHISA3 and RFC3 mRNA levels in 10 tissues from 6 sheep. The results showed that SNPs in the NC_040257.1:c.625 T > C and NC_040261.1:g.9905 T > C were analyzed whether they were associated to feed efficiency parameters in Hu sheep (body weight, feed intake, average daily growth, and feed conversion ratio). NC_040257.1:c.625 T > C was shown to be significantly associated with body weight at 80, 100, and 120 days as well as feed conversion ratio (P < 0.05), whereas NC_040261.1:g.9905 T > C was found to be significantly associated with average daily weight gain from 80-140 days (ADG80-140) and FCR (P < 0.05). In Hu sheep, the CC genotypes of SHISA3 and RFC3 were the most common genotypes related to feed efficiency traits. Furthermore, the feed conversion ratio of the combined genotypes TTSHISA3-CCRFC3, TTSHISA3-CTRFC3, TTSHISA3-TTRFC3, CTSHISA3-CCRFC3 and CTSHISA3-CTRFC3 was significantly better than the FCR of CCSHISA3-TTRFC3. RT-qPCR results showed that the expression levels of SHISA3 were lower in the lung than in spleen, kidney, muscle and lymph (P < 0.05), and RFC3 was the lung had a highly significant higher expression level than the heart, liver, spleen, and muscle (P < 0.01). In conclusion, SHISA3 and RFC3 polymorphisms can be used as genetic markers for improving feed conversion efficiency in Hu sheep.

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