文献类型： 外文期刊

作者： Dou, Mingle ¹ ; Li, Ming ¹ ; Zheng, Zhuqing ¹ ; Chen, Qiuming ¹ ; Wu, Yongji ⁶ ; Wang, Jinxin ¹ ; Shan, Huiquan ¹ ; Wang, Fei ¹ ; Dai, Xuelei ¹ ; Li, Yunjia ¹ ; Yang, Zhirui ¹ ; Tan, Guanghui ¹ ; Luo, Funong ¹ ; Chen, Lei ⁷ ; Shi, Yun Stone ⁸ ; Wu, Jiang Wei ¹ ; Luo, Xiong-Jian ⁹ ; Nanaei, Hojjat Asadollahpour ¹ ; Niyazbekova, Zhannur ¹ ; Zhang, Guojie ¹¹ ; Wang, Wen ⁷ ; Zhao, Shanting ⁶ ; Zheng, Wenxin ¹³ ; Wang, Xihong ¹ ; Jiang, Yu ¹ ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shannxi, Peoples R China

2.Univ Konstanz, Dept Biol, Zool & Evolutionary Biol, Univ Str 10, D-78457 Constance, Germany

3.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Hubei, Peoples R China

4.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Hubei, Peoples R China

5.Xinjiang Agr Univ, Coll Anim Sci, Urumqi 830011, Xinjiang, Peoples R China

6.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shannxi, Peoples R China

7.Northwestern Polytech Univ, Sch Ecol & Environm, Xian 710072, Shaanxi, Peoples R China

8.Nanjing Univ, Model Anim Res Ctr, Med Sch, State Key Lab Pharmaceut Biotechnol, Nanjing 210032, Jiangsu, Peoples R China

9.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650204, Yunnan, Peoples R China

10.ACECR, Avicenna Res Inst, Reprod Biotechnol Res Ctr, Tehran 1983969412, Iran

11.Zhejiang Univ, Ctr Evolutionary & Organismal Biol, Sch Med, Hangzhou 310000, Zhejiang, Peoples R China

12.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China

13.Xinjiang Acad Anim Sci, Urumqi 830011, Xinjiang, Peoples R China

14.Northwest A&F Univ, Key Lab Livestock Biol, Yangling 712100, Shaanxi, Peoples R China

期刊名称：SCIENCE ADVANCES （ 影响因子：13.6； 五年影响因子：15.4 ）

ISSN： 2375-2548

年卷期： 2023 年 9 卷 25 期

页码：

收录情况： SCI

摘要： The increased tameness to reduce avoidance of human in wild animals has been long proposed as the key step of animal domestication. The tameness is a complex behavior trait and largely determined by genetic factors. However, the underlying genetic mutations remain vague and how they influence the animal behaviors is yet to be explored. Behavior tests of a wild-domestic hybrid goat population indicate the locus under strongest artificial selection during domestication may exert a huge effect on the flight distance. Within this locus, only one missense mutation RRM1(I241V) which was present in the early domestic goat similar to 6500 years ago. Genome editing of RRM1(I241V) in mice showed increased tameness and sociability and reduced anxiety. These behavioral changes induced by RRM1(I241V) were modulated by the alternation of activity of glutamatergic synapse and some other synapse-related pathways. This study established a link between RRM1(I241V) and tameness, demonstrating that the complex behavioral change can be achieved by mutations under strong selection during animal domestication.