文献类型： 外文期刊

作者： Fang, Lingzhao ¹ ; Teng, Jinyan ² ; Lin, Qing ¹ ; Bai, Zhonghao ¹ ; Liu, Shuli ³ ; Guan, Dailu ⁵ ; Li, Bingjie ⁶ ; Gao, Yahui ² ; Hou, Yali ⁷ ; Gong, Mian ¹ ; Pan, Zhangyuan ⁷ ; Yu, Ying ⁸ ; Clark, Emily L. ⁹ ; Smith, Jacqueline ⁹ ; Rawlik, Konrad ¹¹ ; Xiang, Ruidong ¹² ; Chamberlain, Amanda J. ¹² ; Goddard, Michael E. ¹² ; Littlejohn, Mathew ¹⁶ ; Larson, Greger ¹⁸ ; MacHugh, David E. ¹⁹ ; O'Grady, John F. ¹⁹ ; Sorensen, Peter ¹ ; Sahana, Goutam ¹ ; Lund, Mogens Sando ¹ ; Jiang, Zhihua ²² ; Pan, Xiangchun ² ; Gong, Wentao ² ; Zhang, Haihan ²⁴ ; He, Xi ²⁴ ; Zhang, Yuebo ²⁴ ; Gao, Ning ²⁴ ; He, Jun ²⁴ ; Yi, Guoqiang ²⁴ ; Liu, Yuwen ²⁵ ; Tang, Zhonglin ²⁵ ; Zhao, Pengju ²⁶ ; Zhou, Yang ²⁷ ; Fu, Liangliang ²⁷ ; Wang, Xiao ²⁹ ; Hao, Dan ³⁰ ; Liu, Lei ²⁸ ; Chen, Siqian ⁸ ; Young, Robert S. ³¹ ; Shen, Xia ³¹ ; Xia, Charley ³⁶ ; Cheng, Hao ⁵ ; Ma, Li ³⁸ ; Cole, John B. ³⁹ ; Baldwin, Ransom L. ⁴³ ; Li, Cong-jun ⁴³ ; Van Tassell, Curtis P. ⁴³ ; Rosen, Benjamin D. ⁴³ ; Bhowmik, Nayan ⁴³ ; Lunney, Joan ⁴⁴ ; Liu, Wansheng ⁴⁵ ; Guan, Leluo ⁴⁶ ; Zhao, Xin ⁴⁸ ; Ibeagha-Awemu, Eveline M. ⁴⁹ ; Luo, Yonglun ⁵⁰ ; Lin, Lin ⁵⁰ ; Canela-Xandri, Oriol ⁵² ; Derks, Martijn F. L. ⁵³ ; Crooijmans, Richard P. M. A. ⁵³ ; Godia, Marta ⁵³ ; Madsen, Ole ⁵³ ; Groenen, Martien A. M. ⁵³ ; Koltes, James E. ⁵⁴ ; Tuggle, Christopher K. ⁵⁴ ; McCarthy, Fiona M. ⁵⁵ ; Rocha, Dominique ⁵⁶ ; Giuffra, Elisabetta ⁵⁶ ; Amills, Marcel ⁵⁷ ; Clop, Alex ⁵⁷ ; Ballester, Maria ⁶⁰ ; Tosser-Klopp, Gwenola ⁶¹ ; Li, Jing ¹ ; Fang, Chao ⁶³ ; Fang, Ming ⁶⁴ ; Wang, Qishan ⁶⁵ ; Hou, Zhuocheng ⁸ ; Wang, Qin ⁸ ; Zhao, Fuping ⁷ ; Jiang, Lin ⁷ ; Zhao, Guiping ⁷ ; Zhou, Zhengkui ⁷ ; Zhou, Rong ⁷ ; Liu, Hehe ⁶⁶ ; Deng, Juan ⁶⁶ ; Jin, Long ⁶⁶ ; Li, Mingzhou ⁶⁶ ; Mo, Delin ⁶⁷ ; Liu, Xiaohong ⁶⁷ ; Chen, Yaosheng ⁶⁷ ; Yuan, Xiaolong ² ; Li, Jiaqi ² ; Zhao, Shuhong ²⁷ ; Zhang, Yi ⁸ ; Ding, Xiangdong ⁸ ; Sun, Dongxiao ⁸ ; Sun, Hui-Zeng ⁶⁸ ; Li, Cong ⁶⁹ ; Wang, Yu ⁶⁹ ; Jiang, Yu ⁶⁹ ; Wu, Dongdong ⁷⁰ ; Wang, Wenwen ⁷¹ ; Fan, Xinzhong ⁷¹ ; Zhang, Qin ⁷¹ ; Li, Kui ²⁵ ; Zhang, Hao ⁸ ; Yang, Ning ⁸ ; Hu, Xiaoxiang ⁷² ; Huang, Wen ⁷³ ; Song, Jiuzhou ³⁸ ; Wu, Yang ⁷⁴ ; Yang, Jian ³ ; Wu, Weiwei ⁷⁵ ; Kasper, Claudia ⁷⁶ ; Liu, Xinfeng ¹ ; Yu, Xiaofei ⁷⁸ ; Cui, Leilei ⁷⁹ ; Zhou, Xiang ⁸¹ ; Kim, Seyoung ⁸² ; Li, Wei ⁸³ ; Im, Hae Kyung ⁸⁴ ; Buckler, Edward S. ⁸⁵ ; Ren, Bing ⁸⁸ ; Schatz, Michael C. ⁹⁰ ; Li, Jingyi Jessica ⁹¹ ; Palmer, Abraham A. ⁹² ; Frantz, Laurent ⁹⁴ ; Zhou, Huaijun ⁵ ; Zhang, Zhe ² ; Liu, George E. ⁴³ ;

作者机构： 1.Aarhus Univ, Ctr Quantitat Genet & Genom, Aarhus, Denmark

2.South China Agr Univ, State Key Lab Swine & Poultry Breeding Ind, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Natl Engn Res Ctr Breeding Swine Ind,Coll Anim Sc, Guangzhou, Peoples R China

3.Westlake Lab Life Sci & Biomed, Hangzhou, Peoples R China

4.Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China

5.Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA

6.Scotlands Rural Coll, Dept Anim & Vet Sci, Edinburgh, Midlothian, Scotland

7.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China

8.China Agr Univ, State Key Lab Anim Biotech Breeding, Key Lab Anim Genet Breeding & Reprod,Natl Engn La, Minist Agr & Rural Affairs,Coll Anim Sci & Techno, Beijing, Peoples R China

9.Univ Edinburgh, Roslin Inst, Easter Bush, Edinburgh, Midlothian, Scotland

10.Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush, Edinburgh, Midlothian, Scotland

11.Univ Edinburgh, Ctr Inflammat Res, Baillie Gifford Pandem Sci Hub, Inst Regenerat & Repair, Edinburgh, Midlothian, Scotland

12.AgriBio, Agr Victoria Res, Ctr AgriBiosci, Bundoora, Vic, Australia

13.Baker Heart & Diabet Inst, Cambridge Baker Syst Genom Initiat, Melbourne, Vic, Australia

14.Univ Melbourne, Sch Agr Food & Ecosyst Sci, Parkville, Vic, Australia

15.La Trobe Univ, Sch Appl Syst Biol, Bundoora, Vic, Australia

16.Livestock Improvement Corp, Res & Dev, Hamilton, New Zealand

17.Massey Univ, AL Rae Ctr Genet & Breeding, Palmerston North, New Zealand

18.Univ Oxford, Sch Archaeol, Palaeogen & Bioarchaeol Res Network, Oxford, England

19.Univ Coll Dublin, UCD Sch Agr & Food Sci, Dublin, Ireland

20.Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin, Ireland

21.Univ Coll Dublin, UCD One Hlth Ctr, Dublin, Ireland

22.Washington State Univ, Dept Anim Sci, Pullman, WA USA

23.Washington State Univ, Ctr Reprod Biol, Pullman, WA USA

24.Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China

25.Chinese Acad Agr Sci, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Agr Genom Inst Shenzhen,Key Lab Livestock & Poult, Shenzhen, Peoples R China

26.Zhejiang Univ, Hainan Inst, Yongyou Ind Pk, Sanya, Peoples R China

27.Huazhong Agr Univ, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan, Peoples R China

28.Yazhouwan Natl Lab, Sanya, Peoples R China

29.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Peoples R China

30.Shandong Acad Agr Sci, Poultry Inst, Jinan, Peoples R China

31.Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland

32.Zhejiang Univ, Univ Edinburgh Inst, Haining, Peoples R China

33.Fudan Univ, Sch Life Sci, Ctr Evolutionary Biol, State Key Lab Genet Engn, Shanghai, Peoples R China

34.Fudan Univ, Greater Bay Area Inst Precis Med Guangzhou, Ctr Intelligent Med Res, Guangzhou, Peoples R China

35.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

36.Univ Edinburgh, Lothian Birth Cohort Studies, Edinburgh, Midlothian, Scotland

37.Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

38.Univ Maryland, Dept Anim & Avian Sci, College Pk, MD USA

39.Council Dairy Cattle Breeding, Bowie, MD USA

40.Univ Florida, Dept Anim Sci, Donald Henry Barron Reprod & Perinatal Biol Res P, Gainesville, FL USA

41.Univ Florida, Genet Inst, Gainesville, FL USA

42.North Carolina State Univ, Dept Anim Sci, Raleigh, NC USA

43.ARS, Anim Genom & Improvement Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA

44.ARS, Anim Parasit Dis Lab, BARC, NEA,USDA, Beltsville, MD USA

45.Penn State Univ, Dept Anim Sci, Ctr Reprod Biol & Hlth, Coll Agr Sci, University Pk, PA USA

46.Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada

47.Univ British Columbia, Fac Land & Food Syst, Vancouver, BC, Canada

48.McGill Univ, Dept Anim Sci, Ste Anne De Bellevue, PQ, Canada

49.Agr & Agri Food Canada, Sherbrooke Res & Dev Ctr, Sherbrooke, PQ, Canada

50.Aarhus Univ, Dept Biomed, Aarhus, Denmark

51.Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark

52.Univ Edinburgh, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

53.Wageningen Univ & Res, Anim Breeding & Genom, Wageningen, Netherlands

54.Iowa State Univ, Dept Anim Sci, Ames, IA USA

55.Univ Arizona, Tucson, AZ USA

56.Paris Saclay Univ, GABI, AgroParisTech, INRAE, Jouy En Josas, France

57.CSIC IRTA UAB UB, Dept Anim Genet, Ctr Res Agr Genom, Campus Univ Autonoma Barcelona, Bellaterra, Spain

58.Univ Autonoma Barcelona, Dept Ciencia Anim & Dels Aliments, Bellaterra, Spain

59.CSIC, Barcelona, Spain

60.IRTA, Anim Breeding & Genet Programme, Torre Marimon, Caldes De Montb, Spain

61.Univ Toulouse, INRAE, GenPhySE, ENVT, Castanet Tolosan, France

62.Kunming Univ, Sch Agr & Life Sci, Kunming, Yunnan, Peoples R China

63.LC Bio Technol Co Ltd, Hangzhou, Peoples R China

64.Jimei Univ, Minist Agr & Rural Affairs, Key Lab Hlth Mariculture East China Sea, Xiamen, Peoples R China

65.Zhejiang Univ, Coll Anim Sci, Hangzhou, Peoples R China

66.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu, Peoples R China

67.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou, Peoples R China

68.Zhejiang Univ, Coll Anim Sci, Key Lab Dairy Cow Genet Improvement & Milk Qual R, Hangzhou, Peoples R China

69.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Shaanxi, Peoples R China

70.Chinese Acad Sci, Kunming Inst Zool, Key Lab Genet Evolut & Anim Models, Kunming, Yunnan, Peoples R China

71.Shandong Agr Univ, Coll Anim Sci, Shandong Prov Key Lab Livestock Germplasm Innovat, Tai An, Shandong, Peoples R China

72.China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China

73.Michigan State Univ, Dept Anim Sci, E Lansing, MI USA

74.Sichuan Univ, Inst Rare Dis, West China Hosp, Chengdu, Peoples R China

75.Xinjiang Acad Anim Sci, Inst Anim Sci, Urumqi City, Peoples R China

76.Agroscope Posieux, Anim GenoPhen Anim Prod Syst & Anim Hlth, Fribourg, Switzerland

77.Lanzhou Univ, Coll Ecol, State Key Lab Herbage Improvement & Grassland Agr, Lanzhou, Peoples R China

78.Ocean Univ China, Coll Marine Life Sci, Qingdao, Peoples R China

79.Nanchang Univ, Sch Life Sci, Nanchang, Jiangxi, Peoples R China

80.Nanchang Univ, Human Aging Res Inst, Jiangxi Prov Key Lab Aging & Dis, Nanchang, Jiangxi, Peoples R China

81.Univ Michigan, Dept Biostat, Ann Arbor, MI USA

82.Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

83.Univ Calif Irvine, Dept Biol Chem, Div Computat Biomed, Sch Med, Irvine, CA USA

84.Univ Chicago, Dept Med & Human Genet, Chicago, IL USA

85.Cornell Univ, Sect Plant Breeding & Genet, Ithaca, NY USA

86.Cornell Univ, Inst Genom Divers, Ithaca, NY USA

87.ARS, USDA, Ithaca, NY USA

88.Univ Calif San Diego, Sch Med, Dept Cellular & Mol Med, Ctr Epigenom,Moores Canc Ctr, La Jolla, CA USA

89.Univ Calif San Diego, Sch Med, Inst Genom Med, La Jolla, CA USA

90.Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD USA

91.Univ Calif Los Angeles, Dept Stat & Data Sci, Los Angeles, CA 90095 USA

92.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

93.Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA

94.Ludwig Maximilians Univ Munchen, Palaeogen Grp, Inst Palaeoanat Domesticat Res & Hist Vet Med, Munich, Germany

95.Queen Mary Univ London, Sch Biol & Behav Sci, London, England

期刊名称：NATURE GENETICS （ 影响因子：29.0； 五年影响因子：37.4 ）

ISSN： 1061-4036

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts. For each species, we aim to collect multiomics data, particularly genomics and transcriptomics, from 50 tissues of 1,000 healthy adults and 200 additional animals representing a specific context. This Perspective provides an overview of the priorities of FarmGTEx and advocates for coordinated strategies of data analysis and resource-sharing initiatives. FarmGTEx aims to serve as a platform for investigating context-specific regulatory effects, which will deepen our understanding of molecular mechanisms underlying complex phenotypes. The knowledge and insights provided by FarmGTEx will contribute to improving sustainable agriculture-based food systems, comparative biology and eventual human biomedicine.