Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle
文献类型： 外文期刊
作者： Hu, Xi-Dan 2 ; Chen, Su-Ting 1 ; Yu, Da-Hai 1 ; Li, Shu-Xia 2 ; Cai, Hong 1 ;
作者机构： 1.Peking Univ, Coll Life Sci, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China
2.Xinjiang Acad Anim Sci, Inst Vet Med, Urumqi 830000, Peoples R China
期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）
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收录情况： SCI
摘要： Mycobacterium bovis causes tuberculosis in cattle. Because current therapies inadequately prevent disease spread, new therapies for M. bovis infections are urgently needed. We treated M. bovis-infected cattle with combinations of DNA vaccines, resulting in significantly reduced pulmonary bacterial loads compared with the untreated group. Further, the pathological changes of lungs were also slight and the lesions were limited in animals treated with the combined DNA vaccines, whereas untreated animals had extensive lung fibrosis and consolidated lesions. This is the first report of DNA vaccine used to treat M. bovis. Thus, combined DNA vaccines may provide enhanced immunotherapeutic efficacy for treatment of bovine tuberculosis.
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