文献类型： 外文期刊

作者： Luo, Junyu ¹ ; Qian, Qili ¹ ; Zheng, Wenxin ² ; Gripkauskaite, Ieva ³ ; Wu, Sijie ¹ ; Zhang, Min ² ; Li, Jinxi ⁴ ; Fu, Bingfei ⁷ ; Bhogal, Ranjit ³ ; Murray, Peter ³ ; Rowson, Matthew ³ ; Li, Bin ⁷ ; Xue, Xiangyang ⁶ ; Gu, Xuelan ⁸ ; Yang, Yajun ⁴ ; Jin, Li ¹ ; Gunn, David Andrew ³ ; Wang, Sijia ¹ ;

作者机构： 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Computat Biol, Beijing, Peoples R China

2.Xinjiang Acad Anim Sci, Xinjiang Breeding Sheep & Wool Cashmere Qual Safet, Qual Stand, Inst Anim Husb, Urumqi, Peoples R China

3.Unilever R&D, Colworth Sci Pk, Sharnbrook MK44 1LQ, Beds, England

4.Fudan Univ, State Key Lab Genet Engn, Shanghai, Peoples R China

5.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Key Lab Contemporary Anthropol,Minist Educ, Shanghai, Peoples R China

6.Fudan Univ, Human Phenome Inst, Shanghai, Peoples R China

7.Fudan Univ, Inst Intelligent Media Comp, Sch Comp Sci, Shanghai, Peoples R China

8.Unilever R&D, Shanghai, Peoples R China

9.Fudan Taizhou Inst Hlth Sci, Taizhou, Peoples R China

10.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Peoples R China

关键词： computer modelling; hair growth; hair treatment

期刊名称：INTERNATIONAL JOURNAL OF COSMETIC SCIENCE （ 影响因子：2.3； 五年影响因子：2.6 ）

ISSN： 0142-5463

年卷期： 2023 年 45 卷 4 期

页码：

收录情况： SCI

摘要： ObjectivesScalp hair has the greatest number of hairs (typically 1-5) per follicular unit but is also the most susceptible body site to hair loss with age. Hence, we set-out to determine the degree to which scalp hair parameters change with age in women and men, any sex differences thereof and whether hair loss is random across follicular units. MethodsA retrospective cross-sectional study of 200 Chinese men and 200 Chinese women (30-69 years). Image analysis and manual counting methods were used to measure occipital located hair parameters from 6 x 8 mm shaved scalp photographs and plucked hair microscopy images. ResultsOf the five hair parameters, the number of hairs per follicular unit had the greatest (negative) correlation with age in both men and women. Men had a greater number of hairs and follicular units than women on average but had a greater decrease in the number of hairs per follicular unit with age, particularly for the loss of multi-hair (3+) follicular units. The loss of hairs with age was significantly different to that expected by a random loss of hairs across follicular units and better described by a model of increased hair loss risk the greater number of hairs per follicular unit. ConclusionsWe have found evidence of hair loss preferentially occurring in multi-hair follicular units, which was more pronounced in men. These data suggest that part of the reason scalp hair is more susceptible to hair loss than on other body sites is due to the greater presence of multi-hair follicular units on the scalp.