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Vaccination of bovines against Echinococcus granulosus (cystic echinococcosis)

文献类型： 外文期刊

作者： Heath, David D. 1 ; Robinson, Christine 1 ; Shakes, Trevor 1 ; Huang, Yan 2 ; Gulnur, Tursun 3 ; Shi, Baoxing 3 ; Zhan 1 ;

作者机构： 1.AgResearch Ltd, Grasslands Res Ctr, Palmerston North 4442, New Zealand

2.Sichuan Prov Ctr Dis Prevent & Control, Inst Parasit Dis Prevent & Control, Chengdu 610041, Sichuan, Peoples R China

3.Xinjiang Acad Anim Sci, Vet Res Inst, Urumqi 830000, Peoples R China

4.Univ Melbourne, Dept Vet Sci, Ctr Vet Clin, Werribee, Vic 3030, Australia

关键词： Echinococcus granulosus;Cattle;Vaccine;EG95

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

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收录情况： SCI

摘要： Hydatid disease is an important human zoonosis. Humans become infected from carnivores that are infected with the Echinococcus granulosus tapeworm. Carnivores become infected after consuming hydatid cysts from grazing animals, which are generally sheep, goats and cattle. A vaccine, known as EG95, can protect sheep and goats against cystic echinococcosis. This paper describes the adaptation of the EG95 vaccine for use in cattle. The monitoring of results used serology and also infection with E. granulosus eggs, followed by necropsy. Immunisation with living E. granulosus oncospheres showed that cattle could be immunised against E. granulosus. Immunisation of cattle with EG95 plus QuilA was also successful. A dose-response and adjuvant trial showed best results were achieved with 250 mu g of antigen and 5 mg of the adjuvant QuilA, which was 5 times the recommended sheep dose. After two vaccinations given one month apart, 90% protection was maintained for 12 months. At 12 months a third vaccination boosted protection to 99% which was maintained for a further 11 months. (C) 2012 Elsevier Ltd. All rights reserved.

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