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Polymorphism of AA-NAT gene and its relationship with litter size of Jining Grey goat of China

文献类型： 外文期刊

作者： Chu, Mingxing 1 ; Yan, Yan 2 ; Wang, Pingqing 3 ; Guligena; Yang, Huiguo; Hao, Geng; Yu, Jianguo; Tang, Qianq 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Key Lab Farm Anim Genet Resources & Germplasm Inn, Minist Agr, Beijing 100193, Peoples R China

2.Chongqing Univ, Bioengn Coll, Chongqing 400030, Peoples R China

3.Chongqing Univ, Bioengn Coll

关键词： arylalkylamine-N-acetyltransferase (AA-NAT) gene / goat / polym

期刊名称：ANIMAL SCIENCE PAPERS AND REPORTS （ 影响因子：1.078； 五年影响因子：1.097 ）

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收录情况： SCI

摘要： The polymorphisms of arylalkylamine-N-acetyltransferase (AA-NAT) gene in high-prolificacy Jining Grey goat, medium-prolificacy Boer goat and low-prolificacy Liaoning Cashmere, Inner Mongolia Cashmere and Angora goats were detected to analyse their relationships with litter size. Primers (P1-P5) were designed to detect the polymorphisms by PCR-SSCP and PCR-RFLP. For P2, AA, AB and BB genotypes were detected. Sequencing revealed one silent mutation (T132C) of AA-NAT gene in BB in comparison to AA. For P3, CC and CD genotypes were detected and sequencing revealed one mutation (C265T) of AA-NAT gene in CD in comparison to CC, and this mutation resulted in an amino acid change of Arg -> Cys (R89C). The Jining Grey does with genotype CD delivered by 0.56 kids (P<0.05) more than those with CC genotype. For P5, EE, EF and FF genotypes were detected and sequencing revealed one mutation (C586T) of AA-NAT gene in FF in comparison to EE. This mutation caused an amino acid change of Arg -> Trp (R196W). For both P2 and P5, the differences in litter size among three genotypes were not significant in Jining Grey goats (P>0.05). These results preliminarily indicate that allele D at the C265T locus of AA-NAT gene is a potential marker in genetic improvement of litter size in goats.

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