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The protective role of maternal genetic immunization on maternal-fetal health and welfare

文献类型： 外文期刊

作者： Ahmed, Sohail 1 ; Jiang, Xunping 1 ; Liu, Guiqiong 2 ; Yang, Huiguo 4 ; Sadiq, Amber 5 ; Ding, Yi 1 ; Farooq, Umar 1 ; Sha, Yiyu 1 ; Zubair, Muhammad 6 ;

作者机构： 1.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan, Peoples R China

2.Huazhong Agr Univ, Coll Anim Sci & Technol, Lab Sheep & Goat Genet Breeding & Reprod, Wuhan, Peoples R China

3.Key Lab Smart Farming Agr Anim, Wuhan, Peoples R China

4.Xinjiang Acad Anim Sci, Urumqi, Peoples R China

5.Quaid i Azam Univ, Dept Pharm, Islamabad, Pakistan

6.Univ Poonch, Dept Vet Clin Sci, Rawalakot, Pakistan

7.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Hubei, Peoples R China

关键词： colostrum; gene vaccines; gestation period; immune response; maternal immunization; maternal-fetal health; oxidative stress

期刊名称：INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS （ 影响因子：3.8； 五年影响因子：3.7 ）

ISSN： 0020-7292

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Pregnancy is a critical period associated with alterations in physiologic, biologic, and immunologic processes, which can affect maternal-fetal health through development of several infectious diseases. At birth, neonates have an immature immune system that makes them more susceptible to severe viral infections and diseases. For this reason, different maternal nutritional and immunization interventions have been used to improve the immune and health status of the mother and her neonate through passive immunity. Here, we reviewed the protective role of maternal immunization with different types of vaccines, especially genetic vaccines, during pregnancy in maternal-fetal health, immune response, colostrum quality, immune response, and anti-oxidative status. For this purpose, we have used different scientific databases (PubMed and Google Scholar) and other official web pages. We customized the search period range from the year 2000 to 2023 using the key words "maternal immunization" OR "gestation period/pregnancy" OR "genetic vaccination" OR "maternal-fetal health" OR "micronutrients" OR "neonatal immunity" "oxidative stress" OR "colostrum quality". The evidence demonstrated that inactivated or killed vaccines produced significant immune protection in the mother and fetus. Furthermore, most recent studies have suggested that the use of genetic vaccines (mRNA and DNA) during pregnancy is efficient at triggering the immune response in mother and neonate without the risk of undesired pregnancy outcomes. However, factors such as maternal redox balance, nutritional status, and the timing of immunization play essential roles in regulating immune response inflammatory status, antioxidant capacity, and the welfare of both the pregnant mother and her newborn.

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