Rumen microbiome and fat deposition in sheep: insights from a bidirectional mendelian randomization study
文献类型： 外文期刊
作者： Zhang, Yukun 1 ; Zhang, Xiaoxue 5 ; Li, Chong 5 ; Tian, Huibin 1 ; Weng, Xiuxiu 1 ; Lin, Changchun 6 ; Zhang, Deyin 1 ; Zhao, Yuan 1 ; Li, Xiaolong 1 ; Cheng, Jiangbo 1 ; Zhao, Liming 1 ; Xu, Dan 1 ; Yang, Xiaobin 1 ; Jiang, Zhihua 7 ; Li, Fadi 1 ; Wang, Weimin 1 ;
作者机构： 1.Lanzhou Univ, State Key Lab Herbage Improvement & Grassland Agro, Lanzhou 730020, Peoples R China
2.Lanzhou Univ, Key Lab Grassland Livestock Ind Innovat, Minist Agr & Rural Afairs, Lanzhou 730020, Peoples R China
3.Lanzhou Univ, Engn Res Ctr Grassland Ind, Minist Educ, Lanzhou 730020, Peoples R China
4.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, Lanzhou 730020, Peoples R China
5.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou 730046, Peoples R China
6.Xinjiang Acad Anim Sci, Inst Anim Sci, Urumqi 830000, Peoples R China
7.Washington State Univ WSU, Dept Anim Sci, Pullman, WA 99164 USA
8.Washington State Univ WSU, Ctr Reprod Biol, Pullman, WA 99164 USA
期刊名称：NPJ BIOFILMS AND MICROBIOMES （ 影响因子：9.2； 五年影响因子：9.9 ）
ISSN：
年卷期： 2024 年 10 卷 1 期
页码：
收录情况： SCI
摘要： Rumen microbiotas are known to influence the fat deposition (FD) in sheep, but controversy over causality remains unresolved. Here, we performed microbiome-wide association studies (MWAS), microbiome genome-wide association analysis (mbGWAS) and bidirectional mendelian randomization (MR) analyses on 1,150 sheep with genotype data from whole-genome resequencing, 16S rRNA sequencing and multilevel FD-traits data. We quantified the proportion of individual variation in FD-traits explained by host genetics, rumen microbiota, and their interaction effects. We identified 32 rumen microbiota biomarkers including Bifidobacterium that were associated with FD-traits (Padj <0.05). Further, utilizing five MR methods, we identified eight causal associations between marker genera and FD-traits (Padj <0.05), including Butyrivibrio, Olsenella, p-2534-18B5 gut group, Prevotellaceae UCG-003, and Pseudobutyrivibrio causing forward causal effects on FD, and changes in Flexilinea and Suttonella induced by FD. To our knowledge, this is the inaugural attempt to employ MR in sheep to investigate the causal relationships between gastrointestinal microbiota and complex phenotypes, underscoring the potential for developing interventions related to adipose deposition in sheep from the perspective of the rumen microbiome.
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