文献类型： 外文期刊
作者： Zhang, Wenbao 1 ; Zhang, Zhuangzhi 1 ; Yimit, Turhong 1 ; Shi, Baoxin 1 ; Aili, Hasyeti 1 ; Tulson, Gulnor 1 ; You, Ho 1 ;
作者机构： 1.Xinjiang Acad Anim Sci, Xinjiang Vet Res Inst, Urumqi, Xinjiang, Peoples R China
2.Queensland Inst Med Res, Australian Ctr Int & Trop Hlth & Nutr, Mol Parasitol Lab, Brisbane, Qld 4006, Australia
3.Queensland Inst Med Res, A
期刊名称：PLOS NEGLECTED TROPICAL DISEASES （ 影响因子：4.411； 五年影响因子：4.898 ）
ISSN： 1935-2735
年卷期： 2009 年 3 卷 10 期
页码：
收录情况： SCI
摘要： Background: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. Methodology/Principal Findings: A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. Conclusions/Significance: The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy.
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