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Further studies on an intermediate host murine model showing that a primary Echinococcus granulosus infection is protective against subsequent oncospheral challenge

文献类型： 外文期刊

作者： Zhang, WB 1 ; You, H 2 ; Zhang, ZZ 2 ; Turson, G 2 ; Hasyet, A 2 ; McManus, DP 2 ;

作者机构： 1.PO Royal Brisbane Hosp, Queensland Inst Med Res, Mol Parasitol Unit, Brisbane, Qld 4029, Australia

2.PO Royal Brisbane Hosp, Queensland Inst Med Res, Mol Parasitol Unit, Brisbane, Qld 4029, Australia; Xinjiang Acad Anim Sci, Vet Res Inst, Urumqi 830000, Xinjiang, Peoples R China

关键词： Echinococcus granulosus;hydatid disease;oncospheres;hydatid cysts;murine host;protection

期刊名称：PARASITOLOGY INTERNATIONAL （ 影响因子：2.23； 五年影响因子：2.281 ）

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收录情况： SCI

摘要： We describe the use of a murine model to evaluate resistance against subsequent challenge following a primary infection with oncospheres of Echinococcus granulosus. Mice (Kunming strain) were infected with hatched onco-spheres of Echinococcus granulosus; 21 days later a second challenge was given by a different route of infection. A primary infection by intraperitoneal (i.p.) injection stimulated 100 and 90.5 percent protection in terms of reduced cyst numbers against a secondary infection given subcutaneously (s.c.) or intravenously (i.v.), respectively. A primary infection given s.c. followed by i.p. or i.v. challenge resulted in 84.0 and 100 percent protection, respectively. Intravenous infection followed by i.p. or s.c. challenge resulted in 98.5 and 69.4 percent protection, respectively. With the i.v. route of infection, almost all resultant cysts were present in the lungs. The data show that a primary infection with oncospheres can induce total or a high degree of protection against a subsequent challenge and confirms that natural (concomitant) immunity can be stimulated in the intermediate host as the result of a primary infection. This may explain the decline in hydatid infection in sheep older than 2 years in hyper-endemic areas such asthose found in Xingjiang, China. These older sheep may have been earlier infected and have subsequently self-cured, with the primary infection stimulating an immune response that protects the intermediate host animals from further infection.

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