文献类型： 外文期刊
作者： Huang, Yongzhen 1 ; Li, Yunjia 1 ; Wang, Xihong 1 ; Yu, Jiantao 2 ; Cai, Yudong 1 ; Zheng, Zhuqing 1 ; Li, Ran 1 ; Zhang, 1 ;
作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
2.Northwest A&F Univ, Coll Informat Engn, Yangling 712100, Shaanxi, Peoples R China
3.Xinjiang Acad Anim Sci, Key Lab Genet Breeding & Reprod Grass feeding Liv, Minist Agr, Biotechnol Res Inst, Urumqi 830026, Peoples R China
4.Natl Inst Biotechnol & Genet Engn NIBGE, Faisalabad 577, Punjab, Pakistan
5.Pakistan Inst Engn & Appl Sci PIEAS, Islamabad 45650, Pakistan
关键词： copy number variation; species-shared; balancing selection; ruminant livestock
期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：6.038； 五年影响因子：4.754 ）
ISSN： 1674-7305
年卷期：
页码：
收录情况： SCI
摘要： Copy number variation (CNV) is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans, animals and plants. However, the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown. Here, we generated CNV region (CNVR) datasets which were diverged or shared among cattle, goat, and sheep, including 886 individuals from 171 diverse populations. Using 9 environmental factors for genome-wide association study (GWAS), we identified a series of candidate CNVRs, including genes relating to immunity, tick resistance, multi-drug resistance, and muscle development. The number of CNVRs shared between species is significantly higher than expected (P<0.00001), and these CNVRs may be more persist than the single nucleotide polymorphisms (SNPs) shared between species. We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes. This study provides the evidence that balancing selection might be more common in mammals than previously considered, and might play an important role in the daily activities of these ruminant species.
- 相关文献
作者其他论文 更多>>
-
Generation and propagation of high fecundity gene edited fine wool sheep by CRISPR/Cas9
作者：Zhang, Xuemei;Qiu, Meiyu;Han, Bing;Liao, Li;Peng, Xinrong;Lin, Jiapeng;Zhang, Ning;Hai, Lati;Liang, Long;Ma, Yila;Li, Wenrong;Liu, Mingjun;Zhang, Xuemei;Qiu, Meiyu;Han, Bing;Liao, Li;Peng, Xinrong;Lin, Jiapeng;Zhang, Ning;Hai, Lati;Liang, Long;Ma, Yila;Li, Wenrong;Liu, Mingjun
关键词：BMPRIB; CRISPR/Cas 9; Fine wool sheep; Gene edited
-
Identification of microsatellites and their effect on economic traits of Texel x Kazakh sheep
作者：Yang, Cunming;Li, Bin;Zhu, Mengting;Sulaiman, Yiming;Yang, Cunming;Li, Bin;He, Sangang;Liu, Mingjun
关键词：relationship; microsatellite locus markers; genetic diversity; Texel x Kazakh sheep; economic traits
-
Inbreeding patterns and genetic diversity under selection in Teha sheep
作者：Wang, Shunzhe;Liang, Long;Ziyayiding, Dilinigeer;Jiao, Wenjing;Kasimu, Hailati;Liu, Mingjun;He, Sangang
关键词：genetic diversity; genomic inbreeding coefficient; ROH; Teha sheep; candidate genes
-
Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep
作者：Gu, Zhenzhen;Duan, WeiWei;Liu, Mingjun;Gu, Zhenzhen;Duan, WeiWei;Liu, Chenxi;Li, Wenrong;Han, Bin;Liu, Mingjun;Liu, Chenxi;Li, Wenrong;Han, Bin;Liu, Mingjun;Liu, Chenxi;Li, Wenrong;Han, Bin;Liu, Mingjun
关键词：sheep; longissimus dorsi; miRNA; MYH3; myofiber
-
Intelligent application of interactive scale transformer for fine grained feature extraction in sheep
作者：Guo, Xingran;Yu, Haizheng;Liao, Xueying;Zhu, Yongqi;Yu, Haizheng;Bian, Hong;Li, Wenrong
关键词：Sheep detection; Artificial intelligence application; Identity document classification; Kinship recognition; Attention mechanism
-
Machine learning driven multi-omics analysis of the genetic mechanisms behind the double-coat fleece formation in Hetian sheep
作者：Zhang, Yanwei;Xie, Mengwan;Tang, Liping;Zheng, Peiyu;Song, Nannan;Yu, Lijuan;Di, Jiang;Li, Wenrong;Xu, Xinming
关键词：Hetian sheep; Chinese merino sheep; coat fleece type; multi-omics; machine learning
-
The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project
作者：Fang, Lingzhao;Lin, Qing;Bai, Zhonghao;Gong, Mian;Sorensen, Peter;Sahana, Goutam;Lund, Mogens Sando;Li, Jing;Liu, Xinfeng;Teng, Jinyan;Lin, Qing;Gao, Yahui;Pan, Xiangchun;Gong, Wentao;Yuan, Xiaolong;Li, Jiaqi;Zhang, Zhe;Liu, Shuli;Yang, Jian;Liu, Shuli;Yang, Jian;Guan, Dailu;Cheng, Hao;Zhou, Huaijun;Li, Bingjie;Hou, Yali;Gong, Mian;Pan, Zhangyuan;Zhao, Fuping;Jiang, Lin;Zhao, Guiping;Zhou, Zhengkui;Zhou, Rong;Yu, Ying;Chen, Siqian;Hou, Zhuocheng;Wang, Qin;Zhang, Yi;Ding, Xiangdong;Sun, Dongxiao;Zhang, Hao;Yang, Ning;Clark, Emily L.;Smith, Jacqueline;Clark, Emily L.;Smith, Jacqueline;Rawlik, Konrad;Xiang, Ruidong;Chamberlain, Amanda J.;Goddard, Michael E.;Xiang, Ruidong;Xiang, Ruidong;Goddard, Michael E.;Chamberlain, Amanda J.;Littlejohn, Mathew;Littlejohn, Mathew;Larson, Greger;MacHugh, David E.;O'Grady, John F.;MacHugh, David E.;MacHugh, David E.;Jiang, Zhihua;Jiang, Zhihua;Zhang, Haihan;He, Xi;Zhang, Yuebo;Gao, Ning;He, Jun;Yi, Guoqiang;Liu, Yuwen;Tang, Zhonglin;Li, Kui;Zhao, Pengju;Zhou, Yang;Fu, Liangliang;Zhao, Shuhong;Zhou, Yang;Liu, Lei;Zhao, Shuhong;Wang, Xiao;Hao, Dan;Young, Robert S.;Shen, Xia;Young, Robert S.;Shen, Xia;Shen, Xia;Shen, Xia;Xia, Charley;Xia, Charley;Ma, Li;Song, Jiuzhou;Cole, John B.;Cole, John B.;Cole, John B.;Cole, John B.;Baldwin, Ransom L.;Li, Cong-jun;Van Tassell, Curtis P.;Rosen, Benjamin D.;Bhowmik, Nayan;Liu, George E.;Lunney, Joan;Liu, Wansheng;Guan, Leluo;Guan, Leluo;Zhao, Xin;Ibeagha-Awemu, Eveline M.;Luo, Yonglun;Lin, Lin;Luo, Yonglun;Lin, Lin;Canela-Xandri, Oriol;Derks, Martijn F. L.;Crooijmans, Richard P. M. A.;Godia, Marta;Madsen, Ole;Groenen, Martien A. M.;Koltes, James E.;Tuggle, Christopher K.;McCarthy, Fiona M.;Rocha, Dominique;Giuffra, Elisabetta;Amills, Marcel;Clop, Alex;Amills, Marcel;Clop, Alex;Ballester, Maria;Tosser-Klopp, Gwenola;Li, Jing;Fang, Chao;Fang, Ming;Wang, Qishan;Liu, Hehe;Deng, Juan;Jin, Long;Li, Mingzhou;Mo, Delin;Liu, Xiaohong;Chen, Yaosheng;Sun, Hui-Zeng;Li, Cong;Wang, Yu;Jiang, Yu;Wu, Dongdong;Wang, Wenwen;Fan, Xinzhong;Zhang, Qin;Hu, Xiaoxiang;Huang, Wen;Wu, Yang;Wu, Weiwei;Kasper, Claudia;Liu, Xinfeng;Yu, Xiaofei;Cui, Leilei;Cui, Leilei;Zhou, Xiang;Kim, Seyoung;Li, Wei;Im, Hae Kyung;Buckler, Edward S.;Buckler, Edward S.;Buckler, Edward S.;Ren, Bing;Ren, Bing;Schatz, Michael C.;Li, Jingyi Jessica;Palmer, Abraham A.;Palmer, Abraham A.;Frantz, Laurent;Frantz, Laurent
关键词：
