您好，欢迎访问新疆畜牧科学院 机构知识库！

Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness

文献类型： 外文期刊

作者： Pu, Xue 1 ; Ma, Shengchao 2 ; Zhao, Bingru 2 ; Tang, Sen 5 ; Lu, Qingwei 2 ; Liu, Wenna 2 ; Wang, Yaqian 2 ; Cen, Yunlin 1 ; Wu, Cuiling 1 ; Fu, Xuefeng 2 ;

作者机构： 1.Xinjiang Normal Univ, Coll Life Sci, Key Lab Special Environm Biodivers Applicat & Regu, Xinjiang Key Lab Special Species Conservat & Regul, Urumqi, Xinjiang, Peoples R China

2.Xinjiang Acad Anim Sci, Inst Anim Sci, Key Lab Genet Breeding & Reprod Xinjiang Wool Shee, Urumqi, Xinjiang, Peoples R China

3.Xinjiang Agr Univ, Coll Anim Sci, Urumqi, Xinjiang, Peoples R China

4.Nanjing Agr Univ, Coll Anim Sci & Technol, Jiangsu Livestock Embryo Engn Lab, Nanjing, Jiangsu, Peoples R China

5.Xinjiang Acad Anim Sci, Inst Biotechnol, Key Lab Herbivorous Livestock Genet, Minist Agr, Urumqi, Xinjiang, Peoples R China

关键词： Ordos fine wool sheep; six livestock breeds; wool fineness; meta-analysis; WGCNA

期刊名称：FRONTIERS IN GENETICS （ 影响因子：2.8； 五年影响因子：3.3 ）

ISSN：

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Wool plays an irreplaceable role in the lives of livestock and the textile industry. The variety of hair quality and shape leads to the diversity of its functions and applications, and the finer wool has a higher economic value. In this study, 10 coarse and 10 fine ordos fine wool sheep skin samples were collected for RNA-seq, and coarse and fine skin/hair follicle RNA-seq datasets of other five animal breeds were obtained from NCBI. Weighted gene co-expression network analysis showed that the common genes were clustered into eight modules. Similar gene expression patterns in sheep and rabbits with the same wool types, different gene expression patterns in animal species with different hair types, and brown modules were significantly correlated with species and breeds. GO and KEGG enrichment analyses showed that, most genes in the brown module associated with hair follicle development. Hence, gene expression patterns in skin tissues may determine hair morphology in animal. The analysis of differentially expressed genes revealed that 32 highly expressed candidate genes associated with the wool fineness of Ordos fine wool sheep. Among them, KAZALD1 (grey module), MYOC (brown module), C1QTNF6 (brown module), FOS (tan module), ITGAM, MX2, MX1, and IFI6 genes have been reported to be involved in the regulation of the hair follicle cycle or hair loss. Additionally, 12 genes, including KAZALD1, MYOC, C1QTNF6, and FOS, are differentially expressed across various animal breeds and species. The above results suggest that different sheep breeds share a similar molecular regulatory basis of wool fineness. Finally, the study provides a theoretical reference for molecular breeding of sheep breeds as well as for the investigation of the origin and evolution of animal hair.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：新疆畜牧科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台