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Lipid Nanoparticle: Beyond Delivery Vehicle-Unveiling Its Immunological Adjuvant Potential

文献类型： 外文期刊

作者： Amor, Narh Philip 1 ; Guo, Kun 1 ; Zhang, Shun 5 ; Xia, Jun 6 ; Yang, Yong 3 ; Lin, Ang 1 ;

作者机构： 1.Inst Innovat Drug Dev & Life Sci, Innovat Ctr Nucl Acid Med, Wuxi, Peoples R China

2.China Pharmaceut Univ, Nanjing, Peoples R China

3.China Pharmaceut Univ, Inst Translat Med, Nanjing, Peoples R China

4.China Pharmaceut Univ, Ctr Infect Med & Vaccine Res, Sch Basic Med, Nanjing, Peoples R China

5.Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo, Peoples R China

6.Xinjiang Acad Anim Sci, Inst Vet Med, Urumqi, Peoples R China

7.Shandong Univ, Inst Immunopharmaceut Sci, Sch Pharmaceut Sci, Jinan, Peoples R China

关键词： adjuvant; delivery system; ionizable lipid; lipid nanoparticle; mode of action

期刊名称：FASEB JOURNAL （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0892-6638

年卷期： 2025 年 39 卷 10 期

页码：

收录情况： SCI

摘要： Lipid nanoparticles (LNPs) have extensively been used in drug delivery over the years, and the perspective of their significance has been well established. Latest findings have demonstrated the inherent adjuvant capacity of some specific lipid components, especially in stimulating immune compartments, which prompted the rational use of lipid-based delivery vehicles in drug R&D. In this concise review, we summarize current knowledge on the adjuvant properties of LNP, with a particular focus on the key components that mediate such effects. Specifically, we describe the vital role of ionizable lipids in triggering innate immune activation and inflammation and highlight the importance of these lipids in determining vaccine effectiveness or safety. Furthermore, the mechanisms by which LNP enhance the immune response are discussed in detail, shedding light on their potential applications in next-generation vaccine design and development. We also present compelling pre-clinical studies that serve as strong evidence for the adjuvant properties of LNP components in enhancing vaccine immunogenicity.

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