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A Hu sheep genome with the first ovine Y chromosome reveal introgression history after sheep domestication

文献类型： 外文期刊

作者： Li, Ran 1 ; Yang, Peng 1 ; Li, Ming 1 ; Fang, Wenwen 1 ; Yue, Xiangpeng 2 ; Nanaei, Hojjat Asadollahpour 1 ; Gan, Shan 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China

2.Lanzhou Univ, Key Lab Grassland Livestock Ind Innovat,Minist Ed, Coll Pastoral Agr Sci & Technol,Minist Agr & Rura, Engn Res Ctr Grassland Ind,State Key Lab Grasslan, Lanzhou 730020, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China

4.Yunan Agr Univ, Fac Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China

5.Xinjiang Acad Anim Sci, Key Lab Genet Breeding & Reprod Grass feeding Liv, Minist Agr, Anim Biotechnol Res Inst, Urumqi 830026, Peoples R China

6.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China

关键词： Y chromosome; sheep; paternal lineage; introgression; de novoassembly

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：6.038； 五年影响因子：4.754 ）

ISSN： 1674-7305

年卷期：

页码：

收录情况： SCI

摘要： The Y chromosome plays key roles in male fertility and reflects the evolutionary history of paternal lineages. Here, we present ade novogenome assembly of the Hu sheep with the first draft assembly of ovine Y chromosome (oMSY), using nanopore sequencing and Hi-C technologies. The oMSY that we generated spans 10.6 Mb from which 775 Y-SNPs were identified by applying a large panel of whole genome sequences from worldwide sheep and wild Iranian mouflons. Three major paternal lineages (HY1a, HY1b and HY2) were defined across domestic sheep, of which HY2 was newly detected. Surprisingly, HY2 forms a monophyletic clade with the Iranian mouflons and is highly divergent from both HY1a and HY1b. Demographic analysis of Y chromosomes, mitochondrial and nuclear genomes confirmed that HY2 and the maternal counterpart of lineage C represented a distinct wild mouflon population in Iran that diverge from the direct ancestor of domestic sheep, the wild mouflons in Southeastern Anatolia. Our results suggest that wild Iranian mouflons had introgressed into domestic sheep and thereby introduced this Iranian mouflon specific lineage carrying HY2 to both East Asian and Africa sheep populations.

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