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Comparative Metabolomics Revealed the Potential Antitumor Characteristics of Four Endophytic Fungi of Brassica rapa L.

文献类型： 外文期刊

作者： Wei, Jie 1 ; Chen, Feng 1 ; Liu, Yumei 1 ; Abudoukerimu, Azierguli 1 ; Zheng, Qian 1 ; Zhang, Xiaobo 1 ; Sun, Yuping 1 ;

作者机构： 1.Xinjiang Med Univ, Urumqi 830000, Xinjiang, Peoples R China

2.Xinjiang Acad Anim Sci, Inst Vet Med, Urumqi 830000, Xinjiang, Peoples R China

期刊名称：ACS OMEGA （ 影响因子：3.512； 五年影响因子：3.613 ）

ISSN： 2470-1343

年卷期： 2020 年 5 卷 11 期

页码：

收录情况： SCI

摘要： Endophytic fungi of medicinal plants have attracted wide attention due to their various active biochemical substances that are similar to those of the host plants and can be easily fermented and cultured. As a traditional medicine and food homologous plant in Xinjiang, Brassica rapa L. has a long history of applications. Recently, it has been shown that B. rapa L. has hypoglycemic, antimicrobial, immunomodulatory, and antioxidant properties. However, there are no studies on the function and diversity of enophytic fungi of B. rapa L. Four endophytic fungus (pr6, pr7, pr8, and pr10) strains were isolated from B. rapa L. in our laboratory. The metabolic extracts from pr10 have significant effects in terms of antitumor activity. In this study, in terms of types and contents, compared with those of the other three endophytic fungi, the dominant metabolites of pr10 were determined by comparative metabolomics analysis. The results of metabolomics analysis indicated that the metabolites of pr10 are rich in amino acids and sugar derivatives such as trehalose, whose ability to inhibit the A549 cell line has been proved. This study provides a theoretical basis for the development and utilization of B. rapa L. and its endophytic fungi to form antitumor agents.

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