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Antibiofilm activity of polyethylene glycol-quercetin nanoparticlesloaded gelatin-N,O-carboxymethyl chitosan composite nanogels against Staphylococcus epidermidis

文献类型： 外文期刊

作者： Luo, Wanhe 1 ; Jiang, Yongtao 1 ; Liu, Jinhuan 1 ; Sun, Beibei 3 ; Gao, Xiuge 4 ; Algharib, Samah Attia 5 ; Guo, Dawei 4 ; Wei, Jie 6 ; Wei, Yurong 6 ;

作者机构： 1.Tarim Univ, Coll Anim Sci & Technol, Engn Lab Tarim Anim Dis Diag & Control, Alar 843300, Peoples R China

2.Sichuan Agr Univ, Dept Pharm, Lab Sustainable Antimicrobials, Chengdu 610000, Peoples R China

3.Tarim Univ, Instrumental Anal Ctr, Alar 843300, Peoples R China

4.Nanjing Agr Univ, Coll Vet Med, Engn Ctr Innovat Vet Drugs, Ctr Vet Drug Res & Evaluat, Nanjing 210095, Peoples R China

5.Benha Univ, Fac Vet Med, Dept Clin Pathol, Moshtohor 13736, Toukh, Egypt

6.Xinjiang Acad Anim Sci, Inst Vet Med, Xinjiang Key Lab Anim Infect Dis, Urumqi 830000, Peoples R China

关键词： Staphylococcus epidermidis; quercetin; biofilm; nanogels; on-demand release

期刊名称：JOURNAL OF VETERINARY SCIENCE （ 影响因子：1.8； 五年影响因子：1.7 ）

ISSN： 1229-845X

年卷期： 2024 年 25 卷 2 期

页码：

收录情况： SCI

摘要： Background: Biofilms, such as those from Staphylococcus epidermidis, are generally insensitive to traditional antimicrobial agents, making it difficult to inhibit their formation. Although quercetin has excellent antibiofilm effects, its clinical applications are limited by the lack of sustained and targeted release at the site of S. epidermidis infection. Objectives: Polyethylene glycol-quercetin nanoparticles (PQ -NPs) -loaded gelatin-N,Ocarboxymethyl chitosan (N,O-CMCS) composite nanogels were prepared and assessed for the on -demand release potential for reducing S. epidermidis biofilm formation. Methods: The formation mechanism, physicochemical characterization, and antibiofilm activity of PQ-nanogels against S. epidermidis were studied. Results: Physicochemical characterization confirmed that PQ-nanogels had been prepared by the electrostatic interactions between gelatin and N,O-CMCS with sodium tripolyphosphate. The PQ-nanogels exhibited obvious pH and gelatinase-responsive to achieve on -demand release in the micro -environment (pH 5.5 and gelatinase) of S. epidermidis. In addition, PQ-nanogels had excellent antibiofilm activity, and the potential antibiofilm mechanism may enhance its antibiofilm activity by reducing its relative biofilm formation, surface hydrophobicity, exopolysaccharides production, and eDNA production. Conclusions: This study will guide the development of the dual responsiveness (pH and gelatinase) of nanogels to achieve on -demand release for reducing S. epidermidis biofilm formation.

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