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Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum-Gelatin Composite Nanogels

文献类型： 外文期刊

作者： Li, Xianqiang 1 ; Liu, Jinhuan 2 ; Dou, Jinfeng 1 ; Li, Chao 4 ; Jiang, Yongtao 2 ; Dawood, Ali 7 ; Wei, Jie 8 ; Wei, Yurong 8 ; Xiong, Youyi 1 ; Luo, Wanhe 2 ; Algharib, Samah 4 ;

作者机构： 1.Anhui Sci & Technol Univ, Coll Life & Hlth Sci, Chuzhou 233100, Anhui, Peoples R China

2.Tarim Univ, Coll Anim Sci & Technol, Engn Lab Tarim Anim Dis Diag & Control, Alar 843300, Xinjiang, Peoples R China

3.Tarim Univ, Coll Anim Sci & Technol, Key Lab Tarim Anim Husb & Sci Technol Xinjiang Pro, Alar 843300, Xinjiang, Peoples R China

4.Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China

5.Huazhong Agr Univ, MARA Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China

6.Benha Univ, Fac Vet Med, Dept Clin Pathol, Toukh 13736, QG, Egypt

7.Univ Sadat City, Fac Vet Med, Med & Infect Dis Dept, Sadat City 32897, Egypt

8.Xinjiang Acad Anim Sci, Inst Vet Med, Xinjiang Key Lab Anim Infect Dis, Urumqi 830000, Xinjiang, Peoples R China

期刊名称：LANGMUIR （ 影响因子：3.9； 五年影响因子：3.8 ）

ISSN： 0743-7463

年卷期： 2024 年 40 卷 9 期

页码：

收录情况： SCI

摘要： Tildipirosin has no significant inhibitory effect on intracellular bacteria because of its poor membrane permeability. To this end, tildipirosin-loaded xanthan gum-gelatin composite nanogels were innovatively prepared to improve the cellular uptake efficiency. The formation of the nanogels via interactions between the positively charged gelatin and the negatively charged xanthan gum was confirmed by powder X-ray diffraction and Fourier transform infrared. The results indicate that the optimal tildipirosin composite nanogels possessed a 3D network structure and were shaped like a uniformly dispersed ellipse, and the particle size, PDI, and zeta potential were 229.4 +/- 1.5 nm, 0.26 +/- 0.04, and -33.2 +/- 2.2 mV, respectively. Interestingly, the nanogels exhibited gelatinase-responsive characteristics, robust cellular uptake via clathrin-mediated endocytosis, and excellent sustained release. With those pharmaceutical properties provided by xanthan gum-gelatin composite nanogels, the anti-Staphylococcus aureus activity of tildipirosin was remarkably amplified. Further, tildipirosin composite nanogels demonstrated good biocompatibility and low in vivo and in vitro toxicities. Therefore, we concluded that tildipirosin-loaded xanthan gum-gelatin composite nanogels might be employed as a potentially effective gelatinase-responsive drug delivery for intracellular bacterial infection.

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