文献类型： 外文期刊
作者： Wang, Yu 1 ; Zhang, Chenzhou 2 ; Wang, Nini 1 ; Li, Zhipeng 3 ; Heller, Rasmus 4 ; Liu, Rong 5 ; Zhao, Yue 1 ; Han, Jiang 1 ;
作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China
2.Northwestern Polytech Univ, Ctr Ecol & Environm Sci, Xian 710072, Shaanxi, Peoples R China
3.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Dept Special Anim Nutr & Feed Sci, Changchun 130112, Jilin, Peoples R China
4.Univ Copenhagen, Dept Biol, Sect Computat & RNA Biol, DK-2100 Copenhagen, Denmark
5.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
7.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China
8.Northwestern Polytech Univ, Sch Life Sci, Ctr Special Environm Biomech & Biomed Engn, Xian 710072, Shaanxi, Peoples R China
9.Sichuan Inst Musk Deer Breeding, Chengdu 610000, Sichuan, Peoples R China
10.Shihezi Univ, Coll Life Sci, Shihezi 832003, Xinjiang, Peoples R China
11.Xinjiang Acad Anim Sci, Key Lab Anim Biotechnol Xinjiang, Urumqi 830026, Xinjiang, Peoples R China
12.Recombinet Inc, St Paul, MN 55104 USA
13.BGI Shenzhen, China Natl GeneBank, Shenzhen 518083, Peoples R China
14.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
15.Univ Copenhagen, Dept Biol, Sect Ecol & Evolut, DK-2100 Copenhagen, Denmark
期刊名称：SCIENCE （ 影响因子：47.728； 五年影响因子：51.433 ）
ISSN： 0036-8075
年卷期： 2019 年 364 卷 6446 期
页码：
收录情况： SCI
摘要： Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.
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