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Genetic Characterization of a Novel Mutant of Peste Des Petits Ruminants Virus Isolated from Capra ibex in China during 2015

文献类型： 外文期刊

作者： Zhu, Zixiang 1 ; Zhang, Xiaocui; Adili, Gulizhati; Huang, Jiong; Du, Xiaoli 1 ; Zhang, Xiangle 1 ; Li, Pengfe 1 ;

作者机构： 1.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr,State Key Lab Vet Etiol Biol, Natl Foot & Mouth Dis Reference Lab,Key Lab Anim, Lanzhou 730046, Gansu, Peoples R China

2.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr,State Key Lab Vet Etiol Biol, Natl Foot & Mouth Dis Reference Lab,Key Lab Anim, Lanzhou 730046

期刊名称：BIOMED RESEARCH INTERNATIONAL （ 影响因子：3.411； 五年影响因子：3.62 ）

ISSN： 2314-6133

年卷期： 2016 年

页码：

收录情况： SCI

摘要： Peste des petits ruminants virus (PPRV) is the causative agent of peste des petits ruminants (PPR). The spread of PPR often causes severe economic losses. Therefore, special attention should be paid to the surveillance of PPR emergence, spread, and geographic distribution. Here we describe a novel mutant of PPRV China/XJBZ/2015 that was isolated from Capra ibex in Xinjiang province in China 2015. The sequence analysis and phylogenetic assessment indicate that China/XJBZ/2015 belongs to lineage IV, being closely related to China/XJYL/2013 strain. Interestingly, the V protein sequence of China/XJBZ/2015 showed lower homology with other Chinese PPRVs isolated during 2013 to 2014 (94%similar to 95%), whereas it shared 100% identity with three Tibet strains isolated in China 2007. The 3' UTR, V gene, and C gene were determined to be highly variable. Besides, 29 PPR genomic sequences available in GenBank were analyzed in this study. It is the first time to use PPRV genomic sequences to classify the different lineages which confirmed the lineage clustering of PPRVs using N gene 255 bp fragments and F gene 322 bp fragments. In conclusion, our findings indicate that the PPRVs continue to evolve in China, and some new mutations have emerged.

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