Nanobodies derived from Camelids represent versatile biomolecules for biomedical applications
文献类型： 外文期刊
作者： Yu, Xinyu 1 ; Xu, Qilan 1 ; Wu, Yuan 2 ; Jiang, Huijun 3 ; Wei, Wei 4 ; Zulipikaer, Azhati 5 ; Guo, Yan 6 ; Jirimutu 6 ; Che 1 ;
作者机构： 1.Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Nanjing 211166, Peoples R China
2.Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Jiangsu Canc Hosp,Dept Med Oncol, Nanjing 210009, Peoples R China
3.Nanjing Med Univ, Sch Pharm, Nanjing 211166, Peoples R China
4.Southeast Univ, Sch Chem & Chem Engn, Jiangsu Prov Hitech Key Lab Biomed Res, Key Lab Environm Med & Engn,Minist Educ, Nanjing 211189, Peoples R China
5.Xinjiang Acad Anim Sci, Econ & Technol Dev Zone Toutunhe Dist, A Li ShanJie 468, Urumqi 830011, Peoples R China
6.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Dairy Biotechnol & Bioengn, Hohhot 010018, Inner Mongolia, Peoples R China
7.Nanjing Med Univ, Key Lab Antibody Tech, Natl Hlth Commiss, Nanjing 211166, Peoples R China
8.Nanjing Med Univ, Minist Educ, Key Lab Modern Toxicol, Nanjing 211166, Peoples R China
期刊名称：BIOMATERIALS SCIENCE （ 影响因子：6.843； 五年影响因子：6.747 ）
ISSN： 2047-4830
年卷期： 2020 年 8 卷 13 期
页码：
收录情况： SCI
摘要： Nanobodies are antigen binding variable domains of heavy-chain antibodies without light-chains, and these biomolecules occur naturally in the serum of Camelidae species. Nanobodies have a compact structure and low molecular weight when compared with antibodies, and are the smallest active antigenbinding fragments. Because of their remarkable stability and manipulable characteristics, nanobodies have been incorporated into biomaterials and used as molecular recognition and tracing agents, drug delivery systems, molecular imaging tools and disease therapeutics. This review summarizes recent progress in this field focusing on nanobodies as versatile biomolecules for biomedical applications.
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